I want to know what are the most important supplements like vitamins and other things >> and what are their SNPs related response > toxicity and effectiveness?
Supplements should not be used to replace standard diabetes treatment. A number of supplements have shown promise as diabetes treatments.
Cinnamon, Research suggests that cinnamon may help regulate blood sugar. A 2011 study found that it has the potential to significantly decrease fasting blood glucose. Chromium ,is an essential trace element. It is used in the metabolism of carbohydrates.However, research on the use of chromium for diabetes treatment is mixed. Low doses are safe for most people, but there is a risk that chromium could make blood sugar go too low. High doses also have the potential to cause kidney damage.
Vitamin B1, is also known as thiamine. Many people with diabetes are thiamine deficient. This may contribute to some diabetes complications. Low thiamine has been linked to heart disease and blood vessel damage.Thiamine is water-soluble. It has difficulty getting into the cells where it’s needed. However, benfotiamine, a supplemental form of thiamine, is lipid-soluble. It more easily penetrates cell membranes. Some research suggests that benfotiamine can prevent diabetic complications. However, other studies have not shown any positive effects.
Alpha-Lipoic Acid (ALA) is a potent antioxidant. Some studies suggest it may:
reduce oxidative stress
lower fasting blood sugar levels
decrease insulin resistance
However, more research is needed. Furthermore, ALA needs to be taken with caution, as it has the potential to lower blood sugar levels to dangerous levels.
Bitter Melon is traditionally used in Ayurvedic medicine. It has shown some promise as a diabetes treatment in animal and lab studies.
There is limited human data on bitter melon. A recent trial compared its effects to those of metformin. In the trial, bitter melon had a modest effect on blood sugar. However, it was not as effective as metformin.
Green Tea, contains polyphenols, which are antioxidants.
The main antioxidant in green tea is known as epigallocatechin gallate (EGCG). Laboratory studies have suggested that EGCG may have numerous health benefits including:
lower cardiovascular disease risk
improved glucose control
better insulin activity
Studies on diabetic patients have not shown health benefits. However, green tea is generally considered safe.
Resveratrol, is a chemical found in wine and grapes. In animal models, it helps prevent high blood sugar. Animal studies have also shown that it can reduce oxidative stress. However, human data is limited. It is too soon to know if supplementation helps with diabetes.
Magnesium, is an essential nutrient. It helps regulate blood pressure. It also regulates insulin sensitivity. Supplemental magnesium may improve insulin sensitivity in diabetics.
A high magnesium diet may also reduce the risk of diabetes. Researchers have found a link between higher magnesium intake, lower rates of insulin resistance, and diabetes.
Supplements no replace standard diabetes treatment or medical counseling.
The T2M is a chronic disease of nutritional origen non trasmissibile, associated to oxidative stress and for the free radicals generation control is recommended the consumption to 20000 to 30000 ORACs, a supplement with 22900 ORACs and 75% poliphenols is MAQUI5000 an extract of maqui berry available in the market of natural products and nutraceuticals
Neal Barnard wrote a great paper on how lifestyle interventions are one of the best ways of treating diabetes. Supplements are not the solution to the problem (granted some may have certain deficiencies), but permanent lifestyle changes are what they need. Here is the link to the paper: http://care.diabetesjournals.org/content/29/8/1777.abstract
I am also in agreement with Dr.Franscisco, that supplements are not permanent solution. Excess or deficiency of particular supplements may exaggerates the complications further. Excess or less levels of one micronutrient could alter the metabolic changes of other micronutrients. Longer-term therapeutic trials are clearly needed in the future to define the role of supplementation in subjects with diabetes mellitus.
whey protein , my study about whey protein and T2D, shows improvement in Hba1c but in patients without any liver or kidneys problems, and of course you take whey to help not as an alternative to the treatement
First minimise the sugars, fructose and galactose, by avoiding high fructose corn syrup, sucrose, milk, and fruit juice, which cause damage to arteries by glycating protein. Have plenty of vegetables for potassium. Supplement alpha lipoic acid, magnesium, manganese, chromium, vitamin B3 and biotin, for their roles in blood sugar stabilisation. A good quality multivitamin/mineral can supply the manganese, chromium, vitamin B3 and biotin. It should also provide vitamin B2, zinc and copper, which are involved in antioxidant protection. Magnesium glycinate is well absorbed. Evaluate patients clinically or with laboratory tests, for any deficiencies in other nutrients.