Suggestions needed regarding some previous works done in the field of measuring mechanical properties of human brain cortex tissue.
Also the response to stress, strain, compression force that any electrode implanted in the cortex in the top 5-6 mm range will experience.
Dear Sanchit
Giulia Franceschini
THE MECHANICS OF HUMAN BRAIN TISSUE
UNIVERSITY OF TRENTO
Modelling, Preservation and Control of Materials and Structure
Tutor: Prof. Davide Bigoni Co-tutor: Prof. Gerhard A. Holzapfel
Trento, febbraio 200
Below the conclusions of this thesis:
Brain tissue have been found to present distinctive mechanical properties, making them qualitatively similar to filled elastomers under cyclic uniaxial stress and to fine soils obeying consolidation theory under oedometric conditions. However, unlike soils and again similarly to elastomers, the ratio between initial oedometric modulus and initial elastic modulus is large. Our results suggest that mechanical modeling of brain tissue should involve a porosity model to account for the intrinsic porosity of the brain matter, at least in situations where substantial volumetric deformations are involved (during for instance hydrocephalus). Moreover, the drained behavior of brain parenchyma should be treated as a nearly incompressible, nonlinear material, capable of permanent deformations and qualitatively similar to rubber-like materials. Although in the present thesis we did not attempt to develop a constitutive model for the description of the mechanical behaviour of brain tissue under arbitrary deformations, we have shown that this model should reduce to Terzaghi theory, when small deformations occur due to the consolidation, and to a theory describing nearly incompressible rubber-like materials, when large deviatoric deformation are involved
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