Lipids are susceptible to oxidation when exposed to free radicals. Polyunsaturated fatty acids are particularly vulnerable to lipid peroxidation resulting in cell damage. What are the harmful effects of lipid peroxidation on health?
The lipid peroxidation products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity. Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders.
Article Lipid Peroxidation Products in Human Health and Disease
LOPs may penetrate cellular membranes, allowing their entry into particular intracellular sites/organelles where many critical metabolic processes occur.
https://www.aocs.org/stay-informed/inform-magazine/featured-articles/detection-monitoring-and-deleterious-health-effects-of-lipid-oxidation-november/december-2014?SSO=True
Also, kindly check:
Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes
Article Editorial: Impact of Lipid Peroxidation on the Physiology an...
Dear Dr. Manal Hadi Kanaan Thanks a lot for your kind contribution and valuable replies on the deleterious effects of lipid peroxidation on health. Many thanks also for sharing valuable links that enriched this discussion. My sincere gratitude.
It is my pleasure Dear Dr. Salman Kadhum Ajlan my sincere gratitude
Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. Injure to mitochondria induced by lipid peroxidation can direct to further ROS generation.
Dear Dr. Lamia Mustafa Al-Naama Many thanks for your kind contribution and valuable reply with which I fully agree. My sincere gratitude.
Please see also these articles
Article Interaction of aldehydes derived from lipid peroxidation and...
Article Potential Adverse Public Health Effects Afforded by the Inge...
Dear Dr. Manal Hadi Kanaan We are grateful for your valuable participation that greatly enriched the discussion. Best wishes.
Dear Dr. Lamia Mustafa Al-Naama Many thanks for sharing valuable links with important topics to enrich this discussion. Kind regards.
Dear Dr. بيداء عبد السلام مهدي Many thanks for your kind contribution and reply. Best regards.
Lipid peroxidation has been implicated in various diseases and pathological conditions, such as carcinogenesis, cardiovascular diseases, neurodegeneration, etc. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834518/
The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity. https://www.hindawi.com/journals/omcl/2013/583438/
Read this paper.
https://academic.oup.com/cardiovascres/article/47/3/410/341966
Dear Dr Chinaza Godswill Awuchi Many thanks for your kind contribution and valuable replies with regard to adverse consequences of lipid peroxidation. Also, sharing valuable links that greatly enriched the discussion is gratefully acknowledged. My sincere gratitude.
Dear Dr. Kiprotich Kiptum Many thanks for your kind contribution and sharing valuable link to enrich this discussion. My sincere gratitude.
Respeted Dr. Salman Ajlan,
Free radicals (OH, NO, CO), superoxide and ONOO- ions are generated as a byproduct of Oxidative Phosphorylation in the mitochondrial ETC and cause lipid peroxidation of PUFA in almost any live cell membrane to induce their structural and functional breakdown. These ROS are implicated in NDDs, CVDs, malignancies, microbial infections, ionization radiation injuries, burns, and numerous inflammatory diseases.
I wish I could write in detail. Since we have high conc of lipids in the CNS, free radical induced lipid peroxidation occurs in the CNS more frequently particularly duiring Stroke, PD, AD, and ALS, in addition to CVDs and Cardiorespiratory arrest causing fatality.
Free radical induced lipid peroxidation in response to DPCI is involved in Charnoly Body formation implicated in numerous acute and chronic diseases in addition to multiple organ failure and fatality due to systemic toximia, hypercytokinemia, and hyperthermia.
You may refer to my recent books "The Charnoly Body, A Novel Biomarker of Mitochondrial Bioenergetics and Charnolophagy in Health and Disease, published by CRC Press, Taylor & Francis Group, Boca Raton, FL, U.S.A.
Good luck with your research.
Respectfully submitted,
Sushil Sharma, Ph.D; DMRIT
Academic Dean
AISM
Dear Dr. Sushil Sharma. Many thanks indeed for your kind contribution and valuable as well as comprehensive reply with regard to lipid peroxidation. My sincere gratitude.
Dear DR. Salman Kadhum Ajlan The peroxidation of membrane lipids can disturb the assembly of cell membranes, which inevitably will impact membrane fluidity, lipid-lipid, and lipid-protein interaction dynamics, membrane permeability, physicochemical properties, ion, and nutrient transport, membrane-initiated signaling pathways, and metabolic processes leading to cell death.
Dear Dr Adjroud Ounassa. Many thanks for your kind contribution and valuable reply with which I fully agree. My sincere gratitude.
Dear Dr Salman Kadhum Ajlan . Enhanced formation of reactive oxygen species (ROS) leads to tissue dysfunction and damage in a number of pathological conditions. Therefore, products of lipid oxidation can extend and propagate the responses and injury initiated by ROS. See the useful RG link:
Article Lipid Peroxidation Products in Human Health and Disease
Kindly see also the very good following link: https://www.sciencedirect.com/topics/neuroscience/lipid-peroxidation
See also the following very good RG link: Article Lipid Peroxidation: Production, Metabolism, and Signaling Me...
Also check the following good RG link:
Article The effects of antioxidant vitamin supplementation on resist...
Kindly visit..
Editorial: Impact of Lipid Peroxidation on the Physiology an...
Also check..
https://www.researchgate.net/publication/8494942_The_effects_of_antioxidant_vitamin_supplementation_on_resistance_exercise_induced_peroxidation_in_trained_and_untrained_participants
Dear Dr Aref Wazwaz. Many thanks indeed for your kind contribution and sharing valuable links that enriched this discussion. My sincere gratitude.
Dear Ca Dr. Gaurav Bhambri. Many thanks indeed for your kind contribution and sharing valuable links to enrich the discussion. Kind regards and best wishes.
تُعرف الصورة المصنّعة من الدهون المتحولة باسم الزيت المهدرج جزئيًا. ولها تأثيرات ضارة بالصحة على مستويات الكوليسترول، وتزيد أيضًا خطر التعرض للنوبات
Dear Dr ابراهيم سلمان الموسوي.. Thank you so much for your kind contribution and comment. My sincere gratitude
Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, inhibition of metabolic processes, causing selective alterations in cell signaling, protein and DNA damage, and cytotoxicity. Injure to mitochondria induced by lipid peroxidation can direct further ROS generation.