It is not justified to refuse considering even the most speculative hypothetical theory or assumption for testing because what is the alternative? The alternative is not to vary features. But without it, no improvements in feature selection are possible. It is still better to have 0.00001% chance of the most speculative hypothetic assumption to change the conditions such that a distinguishing feature gets exposed. Any hypothetic and speculative hypothesis – no matter how unlikely it will be true – is better than the status quo, because it implies changes in feature selection, which is always better than keeping the status quo regarding selected training features. That is why even highly speculative hypothetical assumptions and theories – as long as they do not internally contradict themselves - should not be frowned upon; but instead, they should be very seriously tested. Even if most of them will eventually get disproven, it means progress. Any ruled out hypothesis is progress, because it is a discovery about how aging is not regulated. This excludes many options by giving an example for a way by which aging cannot be manipulated.
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