normal deprotection is by TFA and TFAA in TEA but in my case i Can't see the product, also what is side product?
If you want to convert OMe into OH, then use HBr in acetic acid solvent and reflux, continue adding HBr untill deprotection is complete or you can also use BBr3 (Lewis acid). I hope both of these will work. Best of luck.
Thank you very much Muhammad, can you please send me a paper describing whole protocol for this type of reaction, I mean experimental procedure
J. Org. Chem. 2011, 76, 1804–1813.
Please check supporting information of this paper for the details.
For BBr3, you can search literature, you will find lot of papers using this reagent for demethylation.
Shehzadi,
You may use AcOH, H2, Pd in EtOH, see
--- Shaghafi, Michael B. et al Bioorganic & Medicinal Chemistry Letters, 24(4), 1031-1036; 2014.
As for TFA, you may try once again at 70 C for several hrs (follow by TLC) if you see no reaction then raise the temp. to 100C, see
--- Shah, Shrenik K. et al PCT Int. Appl., 2005044785, 19 May 2005.
Good Luck
Adel Amer, I'll try TFA with high temperature as first method may not suitable for my compounds as they also contain triple bond, that might be reduced in the presence of H2/Pd.
Thanks for suggestion.
It can also be deprotected under mildly oxidizing conditions using DDQ (dichlorodicyanobenzoquinone)
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