We're looking for a dissolution method for isoquercetin containing capsules. Does anyone have some experience or an idea how I can start?

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Tasmiatul Kabir

please follow the link for dissolution for different dosage form..

http://www.pharmacopeia.cn/v29240/usp29nf24s0_c711.html

Annelore Schaut

thank you but the problem is a bit the choice of dissolution media. so far, I only seem to find that isoquercetin is soluble in alkaline solutions, but without solubility data...

Larry L Augsburger

You might find the following article helpful:

“Selected Physical and Chemical Properties of Commercial Hypericum perforatum Extracts Relevant for Formulated Product Quality and Performance,” S. Kopelman et al, The AAPS Journal, 3 (4) article 26 (2001). Isoquercetin was one of the components of Hypericin perforatum extract assayed in this paper.