I have made a deprotection of a ketal to obtain the corresponding ketone. However it was not complete and have still 10% of the protected product. I want to perform a bayer Villiger oxidation on this, it's my goal. Could I make it on this 90% cyclohexanone + 10% of the crude protected cyclohexane-ketal and only perform a silica column purification after the Bayer-Villiger step or it is necessary to perform before the oxidation, already a column purification to remove the 10% of protected product ?
Thank a lot.
Hi, Bolley,
The short answer is yes.10% of the protected reactant will not create any problem in your reaction, you can always clean your product after the oxidation reaction. I would suggest monitoring the reaction by TLC.
Good luck!
Mansour
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