We run a Sciex X500r qToF and tune it once a week currently. I've been told that negative tune has historically been poor on other systems. The peak intensities and width are fine, however the 520.9 m/z precursor ion dips in and out of the upper 2ppm (-2 to +2pmm) range. I can't pinpoint what in the system is causing this and is this something that I should be concerned about?
It seems like you're experiencing fluctuations in mass accuracy for the 520.9 m/z precursor ion during negative tuning on your Sciex X500r qToF. While this may not directly impact peak intensities or width, it could affect data reliability. Here are some steps you could take to address the issue:
1. Check instrument conditions.
2. Verify calibration.
3. Review tuning parameters.
4. Ensure proper sample preparation.
5. Consider external factors.
6. Consult Sciex support if needed.
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