Dear Riya Patel, PCL is not soluble in both water and DMSO (see the table in the ref below), in addition the interaction with the drug make it more nonsoluble. I think the recipe of solvents should be adjusted. My Regards

https://doi.org/10.1016/j.ijpharm.2009.09.023

Dear Riya Patel, PCL is not soluble in both water and DMSO (see the table in the ref below), in addition the interaction with the drug make it more nonsoluble. I think the recipe of solvents should be adjusted. My Regards

https://doi.org/10.1016/j.ijpharm.2009.09.023

Abdelkader BOUAZIZ sir we first dissolved pcl in DCM and then mix both solution drug + dmso and pcl + DCM

Yes I see, but I think the presence of two nonsolvents induce a fast precipitation. Have check if the drug is encapsulated or not.

Abdelkader BOUAZIZ yes sir will check

thank you !!

Abdelkader BOUAZIZ dear sir can you suggest any solvent to dissolve pcl which further not gives precipitation with drug +DMSO

These are interesting documents to follow. If you are following a given protocol check if your PCL MW is in the same range with the one used in the protocol. Good Luck

It is simple, the precipitation occurs because you used water in excess and pcl precipitate in water, to avoid the precipitation make sure that the volume of the dsm used is more then the volume of water. for exemple : dcm=20 ml, water = 5 ml

Hi;

The excessive amount of water that you have added leads to the precipitation of your polymer. Try to increase the volume of DCM compared to water to keep your polymer in solution (about 3 to 5 times the volume of water)

With my best regards

Doufnoune RACHIDA Rachida and Hodhaifa Derdar today we tried the reduce amount of water and increase amount of solvent but we get some clusters which is strechable I atached below

Dear Riya Patel, try with another solvant wich is soluble in water (THF fo exemple) but this time with an amount of 10% of water compared with THF.