Dear All,

I have a hypothetical question which resembles my current problem. any guidance will be helpful to understand my current observations in the study.

Let's assume that:

1. I have a polymer having alternate units of 2 types of monomers, First type of  monomer can easily go from state A-B while for another one A-B transition is difficult.

Now, If I want to imagine a potential of mean force for complete A-B transition of a polymer ,

1. will it be zig-zag PMF due to odd-even effect?

2. How can one prove cooperativity in such transition?

Thanks once again for reading, any help will be really appreciated.