How to dock and simulate multiple protein ligands on single RNA binding site simultaneously?

I have approx. 150 protein ligands and want to dock all 150 protein ligand on single RNA at a time. Is there any tool available for this particular purpose.

01 February 2019 4,450 2 View

How to prepare protein-ligand complex pdb for generating 2-D figure in LigPlot?

I have a pdb file of docked complex of protein and ligand from patchdock, but there is an error occurring when I am importing it to LigPlot.

01 February 2019 2,724 10 View

How to implement neomodal driver of python to implement neo4j database in my local website?

I need to integrate an existing neo4j-database into my django project using your package. Is there any best practice or things I need to consider to do this?

10 November 2018 9,306 0 View

What are the way to retrive data from different columns of existing tables in database by selecting checkbox through php?

I have a multiple checkbox (about 40) in search form of my website. This checkbox contain names of tables stored in database. I am unable to fetch data from columns of the tables in database by...

07 August 2018 4,176 1 View

How to implement graph network built on neo4j browser into our locally built website?

I built a network graph between RBP and non coding element on the basis of positive and negative value of correlation which is statistical parameter on neo4j browser. I just want to impliment this...

07 August 2018 4,494 2 View

How to retrive multiple data stored in database using checkbox through php?

I made a website where in my search page. I gave checkbox option to retrive data which are stored in our database. when I click on multiple checkbox, I am unable to find the result. what can I do,...

07 August 2018 4,769 3 View

Anyone please tell me how to built RBP-miRNA interaction regulome model?

Q-How can we construct RBP-miRNA interaction base gene expression regulatory network from CLIP-seq ,RNA-seq and miRNA seq data?

05 June 2018 4,902 4 View

How to write cypher query for neo4j graph database of my sample data file containing 7 different column ?

I have a sample data file which contain following data: hsa-miR-101-3p hsa-mir-101-2 AGO1 AGO2 NA NA NA hsa-miR-101-3p hsa-mir-101-2 AGO1 AGO3 NA NA NA hsa-miR-101-3p hsa-mir-101-2 AGO1 AGO4 NA...

05 June 2018 8,929 1 View

How do I run a Python script on my web server?

06 July 2017 7,836 1 View

What is the reson for descripancy found in evaluatric parameter for built model?

02 March 2017 9,083 0 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Is this grounds for theophylline toxicity even though her plasma is within the therapeutic range? if it is, how is that possible?

A patient was given 300 mg Theophylline taken twice a day for the treatment of her bronchial asthma and has a positive clinical response. She has been compliant in taking her medication however,...

09 February 2021 3,489 3 View

Difference between assessing EC50 in presence of physiological levels of human serum albumin and alpha1 acid glycoprotein vs. % human serum?

01 February 2021 1,825 1 View

How can we increase awareness about Covid 19 prevention in our city among the local population?

The general public must be made aware of the mode of transmission, presenting symptoms and the measures that can be undertaken to prevent the spread of infection. Few options- Media, Webinars...

03 January 2021 3,538 13 View

Are the receptor proteins on the surface of infected cells will increase or decrease the susceptibility of antivirals?

Are the receptor proteins on the surface of infected cells will increase or decrease the susceptibility of antivirals?

22 December 2020 3,242 4 View

How to convert Terapeutic Human Doses to Cell Experimentation Doses?

"Toxicological evaluations revealed that Cur is found to be pharmacologically safe, even up to 12 g per day, as reported by several animal studies and in phase-I clinical trials Similarly,...

07 December 2020 3,012 1 View

How to increase presynaptic neurotransmitter release artificially?

I would like to pharmacologically increase presynaptic neurotransmitter release in mice CNS in vivo (through the extracellular micro-infusion of a compound). Which strategy would you recommand?...

02 November 2020 5,645 3 View

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30 October 2020 961 3 View

What is the equation used in the calculation of surface area from BET plot?

I want to know the equation that I should use when I calculated the surface area using a plot like this one in the attachment. What are the parameters required for the calculation?

15 October 2020 8,364 6 View

Are there any reasech on loteprednol etabonate microemulsion or nanoemulsion?

The API (i.e. loteprednol etabonate )has poor solubility in water but has excellent solubility in Transcutol P which serves as cosurfactant in my microemulsion formulation. But when I added water...

24 September 2020 417 3 View