Frankly speaking, no standard EBA for tuberculosis persists. The active measures as stand today are precise sputum collection, safety measures of course and the quantitative culture.

Challenging feastures are selection of all patients, safety measures, curtailing contamination and the measured and randomized procedure.

Calculation of bacterial activity is measured as rate of decline in log of colony forming unit(CFU) /ml/day.

But remember, it is only the iceberg of the study. Details, you will get from internet.