Quite a confusing concept to what i know of melatonin induced GABAergic resonse. I found this in the following paper "Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures" 2nd page, 7th line. Please explain.
It has a possibility that suppression of GABA-A receptor in some neuron may result in activation of certain inhibitory neurons involved in regulating seizure and eventually decrease the sensitivity to seizure.
Gabriele Scheler you are absolutely right. Thankyou. The melatonin induced suppression of GABA is pronounced purely in hippocampal region and is also the reason why melatonin receptor antagonists are getting popularity as anti seizure drugs as they suppress this phenomenon and hence GABA levels thrive well wnough to decrease seizure sensitivity.