Hello, I can't understand why a low yield is obtained with the use of HCl in aldol condensation in acid catalysis for the synthesis of hydroxychalcone.
A low yield is obtained with the use of HCl in aldol condensation in acid catalysis for the synthesis of hydroxychalcone . Adol condensation is performed in alkaline medium as it is carbanion addition reaction to carbonyl group . For acid catalysed reaction the enol form must be generated. It is not much favorable with HCl., hence the yield of chalcone is lower .
Thanks for your answer. But why the yield is higher when we use SOCl2/EtOH compared to the mere use of HCl?
Dear Jacqueline Ji
https://www.jpsr.pharmainfo.in/Documents/Volumes/Vol1Issue3/pdf/jpsr01030902.pdf
May be above document clear your query
As mentioned above, if you use dry - gaseous hydrochloric acid, passed through a tube containing a dehydrating agent, then the yield should be higher.
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