Obesity is said to be protective for the women to some extent but to men i donot have idea.

In general post menopausal women are prone to osteoporosis due to deficiency in estradiol. Estradiol may involved in leptin regulation. Female prone to osteoporosis than male

I think this topic can be classified into different domain.

1. Weight is a protect factor for osteoporosis in both genders. But the protect effect may be different between genders.

2. In similar BMI category, higher fat content may be a risk factor for osteoporosis.

3. Underlying disease may be a factor that affect the relationship between weight or obesity and BMD. For example, schizophrenia.

Difficult to say. In our patientgroup with obesity class II - III long lasting obesity-associated D-hypovitaminosis is not gender-dependent, and 2° hyperparathyroidism seems to be more frequent than in a normal weight population with vitamin D-deficiency.

To answer your question is difficult, because in most obesity studies, e.g. bariatric studies:

1. female are overrepresented

2. bone density is not measured, or

3. ther is no validated algorithm wich would allow to compare different studies

The answer to your question could be the next aim of a study of yours ?!

Osteoporosis has traditionally been regarded as a disease of older women. In recent years there has been an increased awareness about osteoporosis in men. Despite growing research, the risk in males continues to be underestimated.

Women mainly develop primary osteoporosis, which is related to the drop in estrogen that occurs at menopause as a normal part of the aging process. In contrast, approximately 50% of male osteoporosis cases have secondary causes.

Osteoporosis in women is primarily related to a pronounced drop in estrogen at menopause. Although some men may have a decline in testosterone with age, it is not equivalent to menopause in women. In fact both testosterone and estrogen are important for maintaining healthy bones in men and women. Healthy testosterone levels are an important part of bone health; however estrogen is likely the primary hormone contributing to bone health in both genders. Estrogen concentrations in men are small but essential to bone health. For men with lower than normal testosterone levels (hypogonadism), testosterone replacement therapy may improve bone health.

Mortality rate from fractures in men are shown by multiple studies to be higher than that of the women.

The World Health Organization has defined osteoporosis based on the bone mineral density values of young adult women. However, fractures in men may occur at higher bone mineral density levels. There is ongoing debate about whether female values are valid in men or if male specific scores should be used.

leptin, an adipocyte-secreted peptide that regulates appetite and energy expenditures, is found to have complex effects on bone. A recent study reported that leptin-deficient and leptin receptor-deficient mice had increased bone formation, In contrast to these findings, however, systemic administration of leptin to leptin-deficient mice, and wild-type mice results in increased bone growth, increased skeletal mass, and increased skeletal strength .

The following links might be of help;

Osteoporosis Caution: Men at Risk - Pri-Med Patient Education Center.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868430/

As it is very debatable issue, I hope these information will be of help to you.

Regards

In my city (Merida Venezuela), the average BMI of 69% in postmenopausal women with spine or hip osteporosis is less than or equal to 26.9 kg/cm2 (unpublished data).,

In our study grous we could not find a coincidence of inflammative obesity parameters (resting metabolis rate, BUN-excretion, C-reactive protein) with degree of vitamin D-insufficiency or even plain deficiency. Not yet.

In our prospectively evaluated bariatric surgery patient group since 1995 we normally see male AND female hypogonadism, e.g. low testosterone an metabolites, as low estradiol and gonadotropine-reaction, what explains the already known and significantly increased rate of hypofertility in females and men. But we didn't observe a link between inflammatory type of obesity, and grade of hypogonadism. It seems, that the bone metabolism and obesity issue goes far beyond sexual hormone action, or leptin which itself is only a small part of a wide endocrinological network in hypothalamus.

Collegue Maliks observation is well known and documented in the acually rare type of Obesity II with earliy Diabetes II with Köln-factor, but I do not know wether the MSC-differentiation in an adult subject ist quantitaively still as importan as in the fetal phase.

The link between osteoporosis (OP) and post-menopause is irrefutable. However, attempting to correlate obesity with OP is problematic. Weight-bearing activity can slow or reverse the progression to OP, hence the more you weigh, the greater the loading and the greater the benefit obtained from resistance-based exercise. However, obesity is frequently accompanied by (or caused by) low levels of activity.

I think the research will lead to different subgroups within the obese category, considering the inadequacy of dietary micronutrients, for example, many of them important for bone metabolism. In this respect, it would be interesting to consider the micronutrients which homeostasis was influenced by the blood levels of estrogen (in the case of postmenopausal women, for example)

With all of the risk factors that obesity represents, I would think that osteoporosis is not something that many doctors or health care professionals would worry about. While inflammation may be the precursor to heart disease, diabetes etc., I have read not read any studies that link the two.

One thing you might consider about gender differences is that very few men will ever experience osteoporosis. This I believe is due to the fact that men die sooner than women.

20% of people with osteoporosis are male... and that may be an underestimate. As life expectancy is increasing for everyone, I think more men will develop this disease. But to say that very few men will experience osteoporosis is, I think, overstating the belief that men don't get it at all.

My group did not focus this question.

I think it would be interesting to study men to actually see when osteoporosis actually starts. Since men seem to stay more active later into life, their bones should be denser than women of the same age.

CAn any one share publictaions with these findings