If you ask about morphological, then sure both will have differences but considering application, you have to be more specific. For instance for chemical sensors, little change in surface morphology can result in different sensing characteristics.

Similarly for any application involving chemical reaction it will have strong impact. For instance, please see this paper:

Cost-effective fabrication of polycrystalline TiO 2 with tunable n/p response for selective hydrogen monitoring

https://www.researchgate.net/publication/326514360_Cost-effective_fabrication_of_polycrystalline_TiO_2_with_tunable_np_response_for_selective_hydrogen_monitoring