Is there a possibility of cross-reaction between SFTSV and DENV, CHIKV, and ZIKV? Will misdiagnosis of SFTSV as dengue possible occur?

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Christian G Meyer

Crossreactivity is very unlikely as SFTSV belongs to the Bunyavirales, CHIKV to the Alphaviridae and DENV and ZIKV to the Flaviviridae.

Cristóvão Figueiredo

It's not impossible, though. But it would be expected to happen mainly with IgM antibodies, that can have several cross-reactions, (even among auto-immune and infectious diseases).

As for dengue, several immunology tests use a combined approach with antibody and antigen (NS1) to try to overcome that issue