1). Is leptin, adiponectin, cortisol, apart from insulin, HbA1c worth measuring in weight loss trial pre and post trial only ?
2). And if it is performed as a repeated measure along a trial for how long would you need to follow a subject in a trial to say it is worth to repeat leptin, adiponectin, or the suggested measures ?
3). Especially what are leptin, adiponectin indicatiors like: are there any kind of changes in fat tissue volume ? (visceral fat or subdermal fat ?)
4). Would you recommend in a shorter trial minimum of 12 weeks to have these measures collected only pre and post trial (and as asked how often would it be worth to collect these along a 1 year trial) ?
5). Is there a massive variation in leptin and adiponectin levels (so should it be collected more than 1 time to estimate somebodies actual value) ? - 5b). Can you give a reference for how to do this ?
6). Can you please indicate hallmark article which describe when these should be measured and what are these indicating really ?
MOST important:
Is there anybody who is interested in being /acting as an external advisor for multicenter RCTs with conditions to be discussed ?
If so please write on: bujpet{AaT]yahoo.co.uk
many thanks,
Peter
Dear sir
Metabolism can roughly be defined as the chemistry that turns food into life, Leptin, insulin and some hormones that plays a key role in regulating energy intake and energy expenditure, are associated with obesity. In some researches showed relation between amounts of leptin in blood with fat mass but need to more than research.please find recent research published in the journal Molecular Cell
Leptin is definitively a good molecule in a weight loss intervention.
Fat tissue modulation is correlated with leptin and resistin levels.
Adiponectin is a secondary modulation of fat expansion and diabetes development.
In clinical, postbariatric context it's not worthwile to measure either of these fat-hormones. Especially Leptin is to dependent from inflammatory system reactions e.g. stress-metabolism with elevated resting metabolic rate (calorimetry), that an indidual, even longitudinal measurement, has no meaning.
Longitudinal Leptin-Adiponektin-measurements, at least for 3 years or longer after bariatric interventions for scientific reasons would be very interesting in dependence of the bariatric technique.
It is well known that plasma levels of leptin elevate with adiposity, on the contraly, those of adiponectin decreases with adiposity, especially visceral adiposity. Therefore ,the plasma levels of both adipocytokines change by weight reduction. However, the signigicance of changes of each adipokine is very different. The change of adiponectin levels is not only a marker of adiposity, but also the normalization of adiponectin levels is very important biomarker for cardiovascular risks.But leptin levels is only a marker for adiposity, so not so important.
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