Yes, it is very much applicable.

There are several algae specific CRISPR methods and papers are available.

For instance,

1. A CRISPR/Cas9 system adapted for gene editing in marine algae https://www.nature.com/articles/srep24951

2. Ajjawi, I., Verruto, J., Aqui, M., Soriaga, L. B., Coppersmith, J., Kwok, K., Moellering, E. R. (2017). Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator. Nature Biotechnology, 35(7), 647–652. https://doi.org/10.1038/nbt.3865

You can also refer this recent review paper for more details.

Application of the CRISPR/Cas system for genome editing in microalgae https://link.springer.com/article/10.1007%2Fs00253-019-09726-x

You can read the following recently publish review article, where you could get your answer as yes:

Application of the CRISPR/Cas system for genome editing in microalgae https://link.springer.com/article/10.1007%2Fs00253-019-09726-x

Thanks for the answers, I have read all the papers in this topic. When I consult with people how haven't done the project, they say it it very difficult to get result. But when I read the papers it seems it is doable and there is chance, specially with recent progress it is more promising. Unfortunately, couldn't get any comment from experienced people.