To give some background, I have had papers rejected before, so it is not something new. But this one stung a little. After meticulously correcting the comments of the reviewers from the first submission, the editor rejected the paper during the SECOND submission, citing a reason given by one reviewer which I feel has been addressed in the paper and in the 'detailed response to reviewers'.

Is there still hope to pursue this by writing to the editor, or will it be a futile struggle?

Advise from editors/reviewers or own experience is greatly appreciated. Thank you!

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