CLICK reaction not working. Is that possible?

I have reacted my alkyne and azide in a solvent mixture of t-BuOH:H2O (1:2), CuSO4.5H2O and Na-Ascorbate. However, I usually obtain a yellow solid after my workup, and when I run an H-NMR analysis...

03 April 2018 4,290 4 View

Down-regulation of mTOR, but upregulation of p-mTOR as shown by western blotting. why is that the case?

We investigated the effect of our compound on mTOR signaling pathway. Western blotting showed that mTOR expression was inhibited but its phosphorylated form was upregulated. However, our qpcr also...

08 September 2017 2,492 0 View

Reaction of chalcones with FeCl3. What is the structure of the resulting complex?

When FeCl2/FeCl3 is added to chalcones, a reddish-brown colour appears, however, the equations for this reaction reported in the literature always show the chalcone as a charge balancing ion,...

08 September 2016 9,845 4 View

Why do I get a very tall peak at about 5ppm for H-NMR?

The H-NMR spectrum of my compound was very neat and peak assignments were smooth and as expected, except for a VERY TALL peak at about 5ppm, what could that be? Is it a solvent peak, or what could...

06 July 2015 9,510 22 View

How can I assess purity via HRMS? What is the acceptable deviation from the calculated mass?

11 December 2014 6,409 13 View

How to avoid the formation of oil droplets during recrystallization?

I have carried out a recrystallization process for my isolated compound from a plant material. I have used ethanol and have allowed it to evaporate under a fumehood with the hope of forming...

05 June 2014 7,832 6 View

Does the pressure(-600 mmHg) affects pH?

When I conducted the degassing experiment using decompression under anaerobic condition(and I used ferrous based chelating agent), the oxidized ferric were observerd. So, could you tell me the...

03 March 2021 4,892 5 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Do anyone here can help us in the field of molecular docking?

We have synthesized various metal complexes with different environment around the metals. Now to see the application of synthesized complexes we need this study also. we are also interested in...

01 March 2021 1,899 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

Distribution of particles in metal matrix?

How would define the "good" and "poor" distribution of particles within the matrix. Is there a quantitative solution to assess the distribution of the particles, which then having denotation of...

28 February 2021 7,397 8 View

Which transition metal salt precursor is best for doping? Why?

I would like to synthesize a transition metal doped TiO2 via solgel method. Hence, I would like to know which metal salt precursor to choose among Chloride, Nitrate, and Sulphate. A clear...

27 February 2021 4,285 3 View

What software programs can directly simulate Additive Manufacturing Directed Energy Deposition (DED)?

I understand there are a lot of software programs that can simulate DED by going through specific modeling, simulation, and commands. For me, that was time consuming and results were not accurate....

24 February 2021 4,428 3 View

It is necessary to reflux the Schiff base and metal salts to obtain metal complex??

24 February 2021 9,166 3 View

How to calculate stress at the cross section of spherical particles within a matrix?

Hi all, I am currently working on some background calculations before I start a new project related to metal matrix particulate composites. I am trying to find a way to calculate the stress at...

19 February 2021 8,503 3 View

What is the detection limit of ED-XRF technique for transition metals in silicon ?

Hi everybody, please, can someone tell us if the transition metals (W, Fe, Ni, etc ...) in silicon destined for solar cell manufacturing can be detected by ED-XRF technique. Note that the...

18 February 2021 6,231 4 View