In the process of systematic review what is difference between methodological qualities assessment and risk of bias assessment of included studies?

Dear Ramesh,

there are various publications, which deal with the compilation / development of systematic reviews. For your important question, I've chosen the following book:

Centre for Reviews and Dissemination, University of York (2009): Systematic Reviews: CRD's guidance for undertaking systematic reviews in health care. see: http://www.york.ac.uk/inst/crd/index_guidance.htm

You can buy this publication; or there's a free download available, see: http://www.york.ac.uk/inst/crd/pdf/Systematic_Reviews.pdf

According to this publication,"risk of bias assessment" is described as a necessary part of quality assessment (see chapter, 1.3.4, pp. 33-44). Performing quality assessment comprises the consideration of several factors like (see p. 33):

• Appropriateness of study design to the research objective

• Risk of bias

• Other issues related to study quality

• Choice of outcome measure

• Statistical issues

• Quality of reporting

• Quality of the intervention

• Generalisability

So the "risk of bias assessment" is just one part of this important process step, when performing systematic reviews.

The authors of the following publication describe the relation / connection between these two terms in the same way:

Shea, B.J., Grimshaw, J.M., Wells, G.A., Boers, M., Andersson, N., Hamel, C., & Bouter, L.M. (2007): Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology, 7(10). see the following links:

http://www.nccmt.ca/registry/view/eng/97.html

http://www.nccmt.ca/registry/pdf/97/en.html

http://www.biomedcentral.com/1471-2288/7/10

http://www.biomedcentral.com/content/pdf/1471-2288-7-10.pdf

Perhaps you are interested also in the following publication, which deals with the topic "risk of bias" extensively:

Viswanathan M, Ansari MT, Berkman ND, Chang S, Hartling L, McPheeters LM, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze A, Treadwell JR. (2012): Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions. Edited by: Agency for Healthcare Research and Quality Methods Guide for Comparative Effectiveness Reviews. AHRQ Publication No. 12-EHC047-EF. See the following links:

www.effectivehealthcare.ahrq.gov/

http://effectivehealthcare.ahrq.gov/ehc/products/322/998/MethodsGuideforCERs_Viswanathan_IndividualStudies.pdf

Good luck with your research project. Kind regards, Detlef

http://www.york.ac.uk/inst/crd/index_guidance.htm

http://www.york.ac.uk/inst/crd/pdf/Systematic_Reviews.pdf

http://www.nccmt.ca/registry/view/eng/97.html

http://www.nccmt.ca/registry/pdf/97/en.html

http://www.biomedcentral.com/1471-2288/7/10

http://www.biomedcentral.com/content/pdf/1471-2288-7-10.pdf

www.effectivehealthcare.ahrq.gov/

http://effectivehealthcare.ahrq.gov/ehc/products/322/998/MethodsGuideforCERs_Viswanathan_IndividualStudies.pdf

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