Polythiophene homopolymer is insoluble in all common solvents, except such harsh solvents as AsF3 or AsF3/thiofuran mixtures. However, several modifications of unsubstituted PT have been made to improve solubility in organic solvents. The incorporation of hydrophilic side chains (e.g. alkyl sulfonates or carboxylates) into the rigid PT's backbone leads to water-soluble (so in alkaline or acidic aqueous solutions) polythiophenes that can be used for the fabrication of thin conductive films.
No, despite being soluble in a number of typical solvents, e.g. tetrahydrofuran, chloroform or chlorobenzene, P3HT is insoluble in water regardless of the pH level.