There is a down regulation of GABA A receptors  after the use of Benzodiazépines whatever it is .

thanks sir for answering

and after withdrawel the GABA A receptors returns to their natural level? how we can make this process faster

If you stop around 40 days they can work again

I suppose an excellent spot to start would be to dive in head first like a champ into the research suggesting that there is not a tolerance anymore than other psychotropic medications used for anxiolytic purposes. Unfortunately I am in a hurry so I will just give a couple of hot leads; 

1) search pubmed for the author "Nardi and clonazepam" and you will find a very thorough series of a longitudinal group of patients taking clonazepam for a duration of 3-years without experiencing tolerance and minimal withdrawal when they wanted to stop. Briefly some patients also used Paroxetine and this drug was less effective and had considerably more side effects (approx. 3x) than clonazepam (REF: Nardi et al., 2013--2016 maybe earlier) {if you really cant find these studies I will be more than happy to give them to you as I have most contemporary writings on the peddling of garbage and the fear mongering of benzodiazepines}.

2) Get real familiar with the structure of the GABA-A receptor although I will assume your current awareness of the 5-subtypes (at least) within this receptor you may not be aware that there is a whole onslaught of slightly varying effects that different benzodiazepines have on them but lead to substantially different (despite the belligerent views of many). A few things that will help you out..

look at the research chemical ETIZOLAM as there are some interesting properties of this particular (triazolothienodiazepiene) including some potential protection against tolerance and the following spike in glutamate after prolonged GABA inhibition (just use Wikipedia, it will give the the citation and you can decide if you like that route or not (route meaning the augmentation of as-of-now legal derivatives to find what your looking for).... However, this leads me to my third hopefully helpful direction: GLUTAMATE INHIBITION, do a pubmed search on memantine (yes, everyones favorite crappy Alzhiemer's Drug Namenda and its prevention of withdrawal from both benz and booze and I believe there are things out there specifically dealing with n-methyl-D-aspartate antagonists (memantine is meant to preserve the continually depleting supply of glutamate in those with worsening dementia) therefore it would stop (theoretically) the withdrawal severity to and the tolerance towards benzodiazepines and friends.

Phenibut is very similar to baclofen and is a phenylated version of gaba allowing for it to cross-over into the Blood-brain-barrier. Everyone will tell you it doesn't bind to GABAA receptors but it does at higher doses (think analogs and isomers then as this is what pregabalin is though a terrible medication [I have never met someone who either just could not stomach it or met the ceiling dose within a month or three].

So I babble: Main things: 1) tolerance, not as bad as you suspect, ITS EASY TO CONVINCE A HYPOCHODRIAC THEY ARE SICK.... SURPRISE!!!!  IT'S EVEN EASIER TO CONVINCE SOMEONE WITH PANIC THAT THE ONE THING BRINGING THEM RELIEF WILL ALL THE SUDDEN STOP AND YOULL BE SHIT OUT OF LUCK.

2)The degree to which benzodiazepine-related molecules exert their effect is strongly (maybe) to the sub-receptor of GABA-A. Also, remember drugs don't typically do only one pharmacodynamic change in your body (i.e. klonopin has serotonergic activity).

3) Get of the defence, you know that benzo WD is the same as ethanol WD which is caused by hyperexcitation of the brain (though benzos don't scramble anything don't  buy the hype, there is no benzodiazepine korsokoff's disease). So thnk about the other side of the spectrum, not what can increase gaba but what can alter glutamate.

I apologize for my lengthy blathering I wish you luck. The 40 day comment from the other person is anecdotal bull so take it with a grain of salt. People have taken that group of medication for more than 3 decades and claim that it still works.

Best wishes,

Logan Netzer

thanks Logan Michael Netzer for your valuable answer

First off Messaoud, I hope you found a good physician to help you safely withdraw from Bromazepam, and did not follow the careless advice from Logan. To everyone that reads Logan’s post, while he makes some good points, I urge you to take everything he says with a huge grain of salt. Benzodiazepines are VERY dangerous drugs and the way he talks so nonchalantly about clonazepam, etizolam (one of the most dangerous benzo analogues in existence) and phenibut (of all things lol) is disturbing to say the least. DO NOT TAKE BENZODIAZEPINES LONG TERM.

No matter how much memantine (yet another dangerous suggestion) or NMDA antagonists you take, the withdrawal will be literal hell. You will likely never be the same person. If you want proof, look at the story of the prestigious Dr. Jordan Peterson. Watch his videos before 2020, then watch interviews after his fiasco with Klonopin.

I’m very willing to discuss the neurochemistry if anyone is interested (post is quite long already).

Stay safe.

Best,

Charles