I have a multiple page tiff file, and I want to edit/crop/remove a part of the image in python,

which is always somewhere at the centre, and keep the rest of the image and then I want to select a particular object from the image which has that centre object removed.(see picture).

The object/region of intrest could be anything or could be anwhere but it wont overlap with the black circle in the centre, and I want the final image with only required intrested object from all the images of constant pixel dimension.

Could anyone suggest where to start, which function can I use.