I am synthesizing a ketonic product which requires Chlorobenzene as solvent. I need to remove it to get pure product. I have tried distillation as azeotropic mixture with water but no use, 2 % still remains. Is there any other way of washing?
You can directly remove it by column chromatrography using hexane as eluent and then adding a more polar solvent to get your ketonic product.
You can directly remove it by column chromatrography using hexane as eluent and then adding a more polar solvent to get your ketonic product.
Thankyou Mr. Robert Göstl for your valuable idea, but the problem is the product is soluble in almost all general organic solvents used in laboratories. I will try the idea in my next batch eith some other solvent.
Mr. Krishnasarma Pathy thanks fro the article. It gave me clear insight. I have tried distillation under vaccum at 740 mmHg and temp 45 C, the disstillation does occur but as i have mentioned 2 % still remains even affter applying higher vaccum.
thankyou Ms. Angela Sastre-Santos ,Column Chromatography is a great tool for purification and i will definately try for saturday's Batch.
Thanx @Zhao Bingtian , can you please explain about "cryodesiccation". I dont have knowledge about it.
Hi, I've looked at all the answers but with experience in the lab simple methods are effective: clearly a column will work as Ms Sastre-Santos suggests. Here is a simple trick- take a large preparative plate (suggest thickest coating possible) and put it in a dry bath flat and take your solution an simply let it drip slowly (in one place) onto plate and watch what happens.!
if you ketonic compound less volatile than CB (131 oC). Put it on high vacuum pump, left it for 2-3 h.
First go with vacuum distillation at appropriate pressure and then, may use solvent in which chloro benzene is soluble but not your product. This type of washing may be helpful.
Chlorobenzene from the Product can be removed by extraction with ether as it is ether soluble.
- Badges
- Science topic
- Similar topics
- Chemistry