I have Pyridine Acetamide . I want to prepare its derivatives with aromatic aniline ? My Acetamide gets hydrolysed in water. And on heating its Acetamide bond breaks
Dear Dr Paradkar the question you proposed is not fully clear. Pyridine if not functionalized with an amino group cannot produce any amide but only acylpyridinuim ions which are unstable intermediates sensitive to moisture, decomposing to reform pyridine and the corresponding acyl acid. May you provide more details or a scheme?