People in attempt of losing weight always experience weight cycling: the repetitions of losing and gaining weight multiple times through their lives, or the so-called “Yo-Yo Effect”. What do you think are the causes of Yo-Yo Effect, and how to overcome them?
The adipose tissues in our body is essential to our health. Initially, the accumulation of fats in our adipose tissue is protective for our body. As this ensures that we only need to eat 2 or 3 meals a day. If we are born without adipose tissue, then, we have to eat every 15 minutes, and 60 meals a day:
https://www.huffpost.com/entry/lizzie-velasquez-adipose-tissue-neonatal-progeroid-syndrome_n_1880875
So the subcutaneous fats (which are the main contributor of our BMI) are protective and normally harmless. Urging the overweight or mildly obese to cut calories and lose weight may actually do more harm than good.
If one is just overweight or slightly obese without any illness, keep a balanced diet, and stop eating 5 hours before going to bed. That's will be enough for keeping one in good health. Weight loss is not necessary for overweight or slightly obese people without accompanied by metabolic syndromes.
Human beings are irrational creatures, we do a lot of things largely relying on unquestioned instincts, because we face so many uncertainties in real life, a decision after careful rational thinking is simply impossible:
https://qz.com/922924/humans-werent-designed-to-be-rational-and-we-are-better-thinkers-for-it/
Apply this to our food consumption, emotional eating and drinking is normal for us, and long-term disciplined rational eating excerted by will power is impossible.
Although restriction of diet often results in initial weight loss, more than 80 per cent of obese dieters fail to maintain their reduced weight. Obese people may regain weight after dieting due to hormonal changes.
Article Long-Term Persistence of Hormonal Adaptations to Weight Loss
It means that even though our weight is reduced, hunger hormones persist to be released in a way by which individual gain weight again.
Sickness is not favorable, and we all wish that we can stay healthy. Yet unfortunately, we may occasionally fall in sickness. take infectious diseases as an example.
During infection, our body need to activate the immune system to fight the pathogens, which imposes large demands on metabolic parameters like nutrition and energy. Therefore, our common understanding will be, we should have aggressive nutrition intake to support our body. Yet, such understanding is actually wrong, and our body will just do the opposite.
The most significant sickness behavior of our body during an infection is a reduction in appetite (infection-induced anorexia). This infection-induced anorexia is our body's defense strategy:
Article Infection-Induced Anorexia: Active Host Defence Strategy
Article Cytokine mediators of malnutrition: clinical implications. T...
During infection a series of metabolic events are activated that leads to a state of negative nitrogen balance and significant loss of lean body mass due to protein breakdown, and liver anabolism. In this way, our body supply itself plenty of nutrition and energy to fight infection and enhance healing, and we are actually not in any forms of starvation at all:
Article Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?
Article Autophagy-A free meal in sickness-associated anorexia
Article Roles of Autophagy in Elimination of Intracellular Bacterial Pathogens
So in case of infection, we should follow our body’s natural reaction, and only eat very little to support our gastrointestinal tract, but keep a serum fasting to ensure the proper functioning of autophagy in fighting the pathogens and recover from the infection.
Has anyone treated Turner's syndrome-related obesity with semaglutide, which improved weight, LFt's(MASLD) benefits? They also have emotional eating and psychological concerns, and how can we stop GLP1 once weight loss has been achieved?
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