hello. I would like to deliver the polymer solution (viscosity 0.001-10 Pa s) to at least 6 tubes at the same time and the delivery rate could also be controlled. would you please give me some suggestions on it?
Scientists from South Korea have succeeded in creating thermally responsive anisotropic nanofibers with two types of compartments for drug delivery. To do so, they co-jetted two polymers side-by-side: thermally-responsive poly(N-isopropylacrylamide)-co-stearyl acrylate, or poly(NIPAM-co-SA), and thermally-unresponsive polyethylene glycol dimethacrylates (PEGDMA).
During electrohydrodynamic jetting, electrodynamic forces are used to generate liquid jets in micro or nano diameters. A jet is produced by applying high voltage between a liquid polymer solution (flowing through a thin capillary) and a conductive substrate. Co-jetting is performed simultaneously from two needles. The resulting product is reminiscent of twisted, bi-colored, nanoscale spaghetti.
Researcher physically crosslinked the first compartment, and chemically stabilized the second with UV. The fibers, which were characterized by confocal laser scanning microscopy and scanning electron microscopy (SEM), were soaked in physiological buffer, turning into hydrogel. Temperature changes made the fiber coil at higher temperatures and uncoil at lower temperatures since only one of the polymers was temperature-sensitive.
Drug Delivery Possibilities
To study drug delivery possibilities, the scientists added two components, bovine serum albumin (BSA) and dexamethasone 21-phosphate (DMP), to the polymer solutions before jetting. Drug release in vitro was measured by UV-visible spectroscopy at different temperatures. As the properties of fiber components charged with temperature, affected either by shape thermo-responsive aggregation or diffusion, the results suggest that created bicompartmental nanofibers could be used for advanced drug delivery systems, when decoupled drug delivery is preferential.
Ive delivered polymer solutions using both syringe pumps and FMI pumps. Syringe pumps are good if you have less than 60 ml of polymer solution to deliver. If you're looking to transfer a volume larger than that I would go with an FMI pump.
Alex,
thank you for your answer. would you please tell me whether FMI pump can pump solution with many tubes？
Im not sure what you mean by "many tubes". But the FMI "outlet" can be split into as many lines as you can engineer. Heres the site.
http://fluidmetering.com/
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