How to carry out stability studies of Novel drug delivery systems such as nanoparticles, liposomes, nano lipid carriers?are there any guidelines?

03 March 2018 1 8K Report

Kindly suggest ASAP

There can be different suggestions depending on which stability you wish to characterise (and the type of the particles).

If chemical - then corresponding spectra, oxidative titration, zeta potential, bending elasticity of the liposomes (reflects chemical condition), concentration of the lipid after extraction plus many other options.

If physical stability: then size and distribution of the suspension (Zetasizer; size-exclusion chromatography; SEM-TEM-optical +++).

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