How strong of a mutation changes an individual’s DNA signature beyond identification? How specifically? Every human constantly mutates yet retains their genetic identity thus, the mutation must be stronger than usual.
Since when they generate a 'DNA finger print' it is normally a consensus sequence i.e., the average of many 'formally equivalent' molecules rather than a single molecule. Therefore it would likely take impossibly massive mutation/DNA modification/degradation to prevent identification.
The rate of mutation is quite low relative to the number of variants that we inherit from the polymorphisms already in the population. So each of our unique traits is inherent from that array of polymorphic differences (which is hundreds of thousand or millions of nucleotide differences). The mutation rate is negligible relative to that.
Considering that most regions used for a DNA fingerprint are from repetitive, non-coding regions, it would be a very tedious and boring project with 0 benefit to the individual.
Besides, we don't have the technology to change your genome in all of your cells once you are more developed than a blastocyst.
A strong mutation that alters an individual's DNA signature beyond simple identification typically involves significant changes in genetic sequences, such as:
Point Mutations: Changes in a single nucleotide that can affect gene function or regulation.
Insertions or Deletions: Adding or removing DNA segments can disrupt gene coding or regulatory regions, leading to altered protein production.
Chromosomal Rearrangements: Large-scale changes like translocations or duplications can affect gene expression and overall genomic stability.
Epigenetic Modifications: Changes that do not alter the DNA sequence but can affect gene expression, such as methylation patterns.
These mutations can lead to phenotypic changes, disease susceptibility, or even contribute to evolutionary adaptations, ultimately affecting an individual's genetic identity.