How probable do individuals have DNA signatures unchangeable by any amount of genetic engineering? Why? How specifically?

https://www.researchgate.net/publication/383114924_EIP_then_RPD

Phillippy, Adam M et al. “Comprehensive DNA signature discovery and validation.” PLoS computational biology vol. 3,5 (2007): e98. doi:10.1371/journal.pcbi.0030098. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868776/ .

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