How many centrioles in each poles of the first mitotic division spindle during the cleavage of the zygote of humans and other mammals (except rodents) ?
In humans (and in rhesus monkeys), each pole of the first mitotic spindle contains one intact (daughter) and one highly degenerated (mother) centriole. See references in (D. Clift & M. Schuh, Nat Rev Mol Cell Biol 2013, 14:549-62).
Hello Vladimir!
Thanks for the reference. Unfortunately without electron microscopy on serial sections answer is still hypothetical. On single sections (Sathananthan AH, et al. Centrioles in the beginning of human development. PNAS U S A. 1991; 88: 4806-10.) in the three-pole mitosis were found one or two centrioles. In his review later this author draws (in the scheme) two centrioles in each pole in the first spindle in the zygote. I hope I will have clean results soon.
Best wishes
and Merry Christmas and Happy New Year!
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