Hi, I'm new to QM/MM calculations, and I've recently started a calculation for a laccase enzyme containing 4 Cu ions. Following the Ambertools MCPB.py tutorial, I've created these files:

lac_small.pdb and lac_small_opt.inp. (There were other files like small_fc and large_mk generated by the MCPB.py script, which are the next step of the calculation requiring additional computation time).

The calculation has been running for 10 days now, with NSEARCH = 51.

Does anyone know how long QM/MM simulations on proteins usually last? I'm rather concerned about my SSD health as it has already rewritten over 8TB of data

Note: I am utilizing 20 CPU threads, no GPU activity i think