It depends. However, it's most prevalent use is in colorectal cancers. There are two main types of injections. Bolus with doses around 400mg/m^2 and infusions around 1000 to 1200mg/m^2 daily.
In general, it can be said that 5-FU has been applied in various chemotherapy regimens in a variety of malignacies, such as bolus doses in 5-day regimens 400-425mg/m in colorectal cancer, that is of no current use, single bolus doses 500-600mg/m in CMF or CAF in breast cancer, regimens that are rather of no utility today, high-dose continuous infusion schedules 500-1000mg/m x 4-5 days in head & neck carcinomas (with CDDP) or stomach cancer (DCF regimen), low-dose continuous ampulatory infusion via portable pump, such as in ECF in advanced gastric cancer (replaced currently by oral Capecitabine; ECX) or colorectal cancer during early 90's, in the De Gramont schedule as a 46-hr infusion after Leucovorin (LV) (mFOLFOX or FOLFIRI regimens in the treatment of colorectal cancer), and at 2600mg/m as 24-hr infusion after LV and Docetaxel (FLOT regimen) in advanced gastric cancer...!!!
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