Reactions can be of different types: addition, substitution (nucleophilic or electrophilic), acid-base reactions [adduct formation, coordination complexes], metathesis, transmetallation etc., One should examine the nature of the compound and what interactions with solvent will enable the compound (solute) to dissolve in it.

Some time reactions can be carried out in solid state by using finely divided particles (grind well in a mixer or using pestle-mortar to increase the surface area) using ball milling (popularly known as mechanochemical method).

Also one can use a solvent in which the reactants are insoluble but still reaction can happen.

If needed use more solvent and generate suspension and reaction can occur.

If it is sparingly soluble in methanol, still reaction can be carried out.

If it is ionic complex, try to substitute the anionic species with a better anion and that should help. If the complex is an anionic species, try to encapsulate the cation using polyethers, cryptands etc. to make it soluble in polar organic solvents.

You can go through this article and hope you will get an idea.

DOI: 10.1039/b802258p

Mahendra Mohan Thanks a lot, I already have read that before, but I couldn't figure out how to perform reactions from previous literature. I tried many reactions without success.

Use your material in amorphous form (large surface area) or micronized if amorphous is not feasible am a solvent that gives you a certain solubility. Do not use diluted solutions because the reaction rate is concentration dependent. Another approach is to use surfactants for solubilization.

I think it depends on what you are trying modify your metal-organic cages with. Mechanochemical methods can be used, however you need to be more specific about the type of interactions or reactions that you expect to happen in your compound.

I think this depends on what you are trying to improve.

Reactions can be of different types: addition, substitution (nucleophilic or electrophilic), acid-base reactions [adduct formation, coordination complexes], metathesis, transmetallation etc., One should examine the nature of the compound and what interactions with solvent will enable the compound (solute) to dissolve in it.

Some time reactions can be carried out in solid state by using finely divided particles (grind well in a mixer or using pestle-mortar to increase the surface area) using ball milling (popularly known as mechanochemical method).

Also one can use a solvent in which the reactants are insoluble but still reaction can happen.

If needed use more solvent and generate suspension and reaction can occur.

If it is sparingly soluble in methanol, still reaction can be carried out.

If it is ionic complex, try to substitute the anionic species with a better anion and that should help. If the complex is an anionic species, try to encapsulate the cation using polyethers, cryptands etc. to make it soluble in polar organic solvents.

Balakrishna Maravanji Thanks a lot for your informative answer that really hints me many ideas to deal with my material.

Andrei Blasko Obinna Chibueze Okpareke Thanks a lot for sharing useful information that guides me

Do you tried solid state reaction? Even though I have no clear understanding about the nature of your reactants (functional groups) You may be effective. Please try it by mixing stoichiometric amount of reactants.

May be you can try to use DESs (deep eutectic solvents) .They are very easy to obtain and it is well documented the enhanced solubility of DES over conventional solvents. Also ternary mixtures of DES/co-solvent (for example DES/H2O) in various ratios allow the tunability of the mixture solubility. Good luck

Americo Lemos Thanks for your idea, I never used before, I will try

May be you can try in solid state with mixing stoichiometric amount of reactants El Sayed M. El Sayed

Thank you very much for your valuable inputs

Hi,

You may try other solvents or you may try to add additives or phase transfer catalysts and so on.