I am working on diabetic retinopathy. For that matter, I have to segment out optic disc as one of the pre-processing step. For this particular step I am following the paper tilted "Automatic Optic Disk Segmentation in Presence of Disk Blurring". I have to create inverted LoG filter similar to the image shown below.

However, I am not able to find how to create such inverted LoG filter in Pyhton. I am using Python 3.6.4 with PyCharm IDE. Can anyone please help me with this.

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