How can I recrystallized the HCl salt of organic compounds such as fluoxetine hydrochloride?
Hello Kobra, fluoxetin HCl salt can be recrystallized from DCM/EtOAc. Another option is to precipitate fluoxetin free base from EtOAc solution by the addition of anhydrous HCl. Check the references: Article Chiral synthesis via organoboranes. 18. Selective reductions...
Article Identification and Comparison of Impurities in Fluoxetine Hy...
Dear
i agree with Maksim Fomin. this method can be used for the preparation of fluoxetine HCl salt. you can also try other solvents such as ether or alcohols to dissolve fluoxetine then start drop wise addition of the ethereal HCl with stirring, where the solution will become turbid due to precipitation of the HCl salt
But, i think your are asking about the re-crystallization of fluoxetin HCl powder, not the synthesis. this may be achieved by dissolving the hydrochloride salt in small volume of polar solvents such as aqueous ethanol and leave a side to slowly evaporate
Recrystallization of the HCl salt of floxetine . Take fluoxetine in benzene , add minimum quantity of HCl till it gets dissolved , warm it & cool slowly ar room temp. The hydrochloride salt separates out as crystalline salt.
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