I had read the article entitled 'Synthesis by precipitation polymerization of molecularly imprinted polymer for the selective extraction of diclofenac from water samples' written by Chao-Meng Dai et al. and it said this but still I could not understand. It seems the procedure is not very clear.
'DFC was extracted into chloroform from an acidic solution in
order to obtain its acid form'.
I want the diclofenac acid to be in solid form.
On page 5 of this MSc thesis(at University of North Carolina, Wilmington, U.S.A) , you will find the procedure to prepare diclofenac acid from its sodium salt. It is an easy procedure which gives the free acid in solid form.
Best wishes for success in your research.
http://libres.uncg.edu/ir/uncw/f/burkej2007-1.pdf
On page 5 of this MSc thesis(at University of North Carolina, Wilmington, U.S.A) , you will find the procedure to prepare diclofenac acid from its sodium salt. It is an easy procedure which gives the free acid in solid form.
Best wishes for success in your research.
http://libres.uncg.edu/ir/uncw/f/burkej2007-1.pdf
Dear all,
what is not mentionned in the document uploaded by Dr. Nizar, is the pH at which sodium carboxylate regain the carboxylic acid form. This is usually took place at pH's from 2 to 3. Regards
Thank you Dr. Abdelkader in mentioning an important factor (the pH) in shifting the (carboxylate carboxylic acid) equilbrium towards the free acid. Please take care of that Nour El-Ein. My regards to all.
We have already tried to use diclofenac acid as a template for MIPs synthesis. But we had the same problem that was mentioned by Miss Nurlin abo samah and we change our template.
Thanks for your explanation and my regards to all
Thank you everyone. Really appreciate those fruitful comments. Thank you Dr Nizar Matar. Dr Abdelkader is there any article that mention about the important factor (pH value) regarding the shifting (carboxylate & carboxylic acid) equlibrium for this procedure?Really appreciate it if you can share the article with us here.
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