I have performed an esterification of 4-carboxybenzaldehyde, and obtained both the aldehydic methyl ester and the methyl ester dimethyl acetal. Does anyone know how I can hydrolyze the acetal back to aldehyde without touching the ester? Is H2O enough? Mildly acidic H2O?
Thank you in advance
Ashis Ranjan Bandyopadhyay
A difficult task ! Separation of the two components appears to me to be relatively easier.
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Nicolas Neuman
Thank you. I already found a paper. Using H2O/MeCN with a few drops of acid, generates hydrolysis of the acetal in 30 minutes more or less. I already did the NMR and it worked.
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Madhukar Baburao Deshmukh
Hydrolyze an acetal in the presence of an ester you can use mild acidic reagent for hydrolysis of acetal as Amberlyst-15 acid resin.?
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