Hi. I want to ask about the effective dose of pregabaline in rats with diabetic neuropathy pain? Maybe somebody investigated pregabaline in streptozo...

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Katsura Tsukamoto

I read the drug information about pregabalin that mentioned it inhibited the diabetic neuropathy pain (static allodynia) induced by STZ in rat with dose dependently more than 3mg/kg, p.o. and 10mg/kg, p.o. for the dynamic allodynia. I guess the reference is following (I did not check it out....)

Field, M. J. et al.：Pain 80（1-2）：391, 1999

Krystyna Cegielska-Perun

Thanks a lot!