The scientists say little about results' reproducibility in the current culture of the life science. We need to discuss more about this topic to improve our science.
Amended on 14 September 2018
This is an interesting question.
Gene expression seems to be ruled by virus in humans and some fetal cells. Bacterial gene expression seems to be ruled by bacterophage or bacterial virus; i.e., becteria (Lactobacillus casei) has 12% amount of phage proteins among bacterial cell proteins. Please see file "HepG2 Fucoidan" for human cells. Please also see file "JMBT Alopecia" for human serum.
Therefore, notorious Genetics or Gene Therapy are not working in humans. Mendel's theory is only true in inbred strain. But, humans is an outbred strain. Mitochondria and Chloroplast seem to be the result of Symbiosis and/or Parasitism by Rickettsia and Cyanobacteria/Blue-green algae, respectively. It is noteworthy that anticancer effect of Japanse edible brown algae Mozuku (Fucoidan) is demonstrated to the outbred rat (SD rat), but is not to the inbred rat (LEW rat) (please see file; Rat DEN Np-Fucoi).
Thus, I am estimating that Microcephaly, Harelip, and Down syndrome are caused by Zika virus/ZIKV or HHV-5/Human cytomegalovirus/HCMV, Hepatitis A virus/HAV or Influenza virus/Flu or Newcastle disease virus/NDV, and Human adenovirus/HAdV, respectively.
The estimation method of harelip is as follows; i.e., HCC tissue (with PBC) has Homeobox protein MSX-1/Hox-7 at 1.1, Androgen receptor/Nuclear receptor subfamily 3, group C, member 4 at 7.1, and Cytokeratin 15/Keratin, type I cytoskeletal 15 at 1.0 μg/mg of tissue protein, respectively. Total harelip-related protein becomes to be 9.1 μg/mg of tissue protein.
Her tissue has up-regulating Genome polyprotein of Hepatitis A virus/HAV at 24.0 μg/mg of tissue protein.
Her tissue also has down-regulating Orthomyxovirus of Hemagglutinin of Influenza A virus/FluA and Influenza B virus/FluB at 6.8 μg/mg of tissue protein, and Paramyxovirus of Hemagglutinin-neuraminidase of Newcastle disease virus/NDV at 7.5 μg/mg of tissue protein, respectively. Total repressing power becomes to be 14.3 μg/mg of tissue protein. Therefore, total inducing power becomes to be 9.7 μg/mg of tissue protein, and this quantity or amount of inducing power has expressed 9.1 μg/mg of tissue protein of harelip-related proteins.
By the way, I have recently published the new way for preventing human diseases (please see file; Feed by Measure).
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