Has anybody worked with Norepinephrine Sulfonic Acid in HPLC?? This molecule seems to be non retainable in Any HPLC column.?

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Tabrez Shaikh

Please find good method for Norepinephrine in below link. Please note that counter ion sulfphonic acid peak will always elute very early.

https://helixchrom.com/applications/hplc-analysis-of-drug-norepinephrine-on-heritage-c18-column-according-to-us-pharmacopeia/

Md. Mostafa Moin

Norepinephrine Bitartrate Injection is drug product which has degradant impurity of Norepinephrine Sulfonic Acid. So need a separate method of this impurity as it is always impacting assay & other parameters. Yes sulfonic acid is always early eluting and this challenge i need overcome therefore i am seeking help.

Thanks