Unlike the other metabolic pathways/ cycles, genetic abnormalities seems not to be common with Kreb's s cycle. Are there genetic abnormalities of Kreb's cycle?
Yes, there are quite a few abnormalities found till date. I hope these papers (see below) will help you know more about disease due to defects in Krebs cycle:
Chapter Disorders of the Krebs Cycle
Article Inborn errors of the Krebs cycle: a group of unusual mitocho...