I can not find the origin of this concept :(
I'm sorry, this is the reference, I have not found anything else. :( Thanks!!
https://archive.org/stream/journalofcancerr5192unse/journalofcancerr5192unse_djvu.txt
http://cancerres.aacrjournals.org/content/amjcancer/35/3/427.full.pdf
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