Experience or expertise with the rodent catalepsy model for assessing EPS liability of Dopamine antagonists?

09 September 2018 1 4K Report

Can you recommend references?

Any suggestions for comparing EPS liability for D2/D3 antagonists that are pGP substrates?

Well, after an exhaustive lit. search and much discussion. We settled on the mouse amphetamine/catalepsy model for assessing CNS binding and the use of CaCo II cells to look at BBB permeability related to PgP.

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