Base deficit, age, injury mechanism, and head injury were associated with mortality using logistic regression. Age less than 55 years, no head injury, and a base deficit of -15 mmol/L were associated with 25% mortality.

It is known fact in critical care that why we target to achieve these value within normal level during resustation

These two studies may can help you

Yes. Response to resuscitation is also determined by these paremeters.

Studies show that lactate level followed by base deficit are more reliable predictor of mortality in traumatic shock...

These two surpass the sensitivity of other biochemical predictors, including pH, anion gap and bicarbonate level...

another human trial showing lactate level correlating with mortality

https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1934409

Please check theses studies

https://journals.lww.com/rca/fulltext/2018/09000/base_deficit,_lactate_clearance,_and_shock_index.5.aspx

https://anesthesiology.pubs.asahq.org/article.aspx?articleid=2598359

Article Lactate and base deficit in trauma: Prognostic value

Yes

Yes in my opnion.

The level of lactatre is directly related to the perfusion of the celular llevel.

The base deficiet is due to compensation of the body to the state of moderate to severe acidosis.

The higher the serum lactate, the worse the degree of shock and the higher the mortality. Lactate levels higher than 4 mmol/L in patients with suspected infection have been shown to yield a 5-fold increase in the risk of death and are associated with a mortality approaching 30%