I am interested in the degradation at 37 degrees, how this changes with poloxamer % and also with poloxamer volume. The only study I have found is published in a Chinese journal that I can´t get a hold of.
I feel the degradation rate will change accompany by lab environment varing from one place to another place. Hence the researchers go for precision conformation. However, there are many mathematical approaches are available to verify rates. Please check free solubility of your compound (In) that from raw (Io) source. In your surfactant may be troubling with ionic interference while go for puedo order reaction, for this case need to maintain the ionic strength of your solution. This one can possible to reduce the errors and carefully read the rate constants and other parameters for an individual rate determining studies. Try to find intrinsic viscosity of your average polymer weight, that also useful to identify the exact rate on various % composition. All the best.
Hi. Since Poloxamer (Pluronic) is an ethylene/propylene oxide polymer, one might expect the degradation to be similar for all these guys. Here is a quick Google Scholar search.