Does AAF-CMK inhibit anything else other than TPP 2?

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Steingrimur Stefansson

Hi Eslam. I suspect that Ala-Ala-Phe-CMK could potentially inhibit many chymotrypsin-like proteinases (Cathepsin G, Chymase, proteasomes, etc)

But in the literature, I could only find that it inhibits kallikrein-7.

http://www.craiklab.ucsf.edu/docs/pub228.pdf

Steven Verhelst

Please note that chloromethyl ketones can also react with cysteine proteases.

Eslam Katab

Thank you so much