One type of gives host to U (hot granite) being well differentiated the others not. The process is too complex so as to be anwered with a simple answer only because in many cases it is not the granite, proper, but igneous rocks associated with the granite such as pegmatite, lamprophyres and veins of different composition that have gentically no link to the hosting granite except undergoing faulting and jointing.
The most obvious indication is radioactivity. while Uranium, itself does not emit Gamma Rays , several of its daughter products do, which is why 1950's era Prospectors used Geiger-Muller tube detectors. However, this can also be misleading, as in Roll-front deposits, such a in the South Texas Roll-Front deposits, where the Uranium concentration is often Down-Dip, from the GR anomaly.